Important issues in developmental toxicity testing

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Important issues in developmental toxicity testing

Correspondence address: Assoc Prof. Eduard Ujházy, PhD. Department of Reproductive Toxicology, Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia, e-mail: [email protected] Studies of individual development and its possible deterioration have been the concern since the 19th century, when Etienne Geoffroy de Saint-Hilaire (1772...

متن کامل

Transcriptomics in developmental toxicity testing

Reproductive toxicity testing is one of the most complex, expensive and labor intensive fields of toxicology (Leist et al. drastically demonstrate the fundamental importance of reliable developmental toxicity tests for human safety (van Recently, human embryonic stem cell based in vitro test systems have been established that recapitulate critical periods of human early development (Krug et al....

متن کامل

IMPORTANT ISSUES IN MULTIPLE RESPONSE OPTIMIZATION

There have been many productive methods developed so far for optimization of multiple response surface (MRS) problems. This paper tends to review the most seminal approaches in MRS and discuss the strength and weakness of each of the approaches through existing aspects in MRS. A numerical example is included to compare results by different methods. Finally some of the prominent areas for future...

متن کامل

Vitamin D testing: three important issues.

In Liverpool we are auditing vitamin D testing and prescribing in primary care, following guidelines issued to GPs in early 2012 to encourage evidenced based testing and prescribing.1 Our data indicates that some GPs are testing in an increasingly non-targeted way. GPs in Liverpool ordered over £100 000 worth of vitamin D tests in 2012, over 10 times the amount spent in 2007. Though more people...

متن کامل

Neurobehavioral aspects of developmental toxicity testing.

Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Interdisciplinary Toxicology

سال: 2008

ISSN: 1337-9569,1337-6853

DOI: 10.2478/v10102-010-0028-9